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Gene Therapy & Genomic Medicine
CRISPR edits, delivery vectors, rare‑disease trials, and approvals.
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Latest in Gene Therapy & Genomic Medicine
Aptamer-Guided CRISPR-Cas9 Delivery Could Make Cancer Genome Editing
3+ hour, 58+ min ago (55+ words) Gene editing has long promised a revolution in cancer medicine, yet the promise has remained stubbornly out of reach for one deceptively simple reason: getting the CRISPR-Cas9 machinery into tumor cells, and only tumor cells, is extraordinarily difficult. A new…...
Short RNA Reads Underestimate A-to-I RNA Editing, Long-Read Sequencing
9+ hour, 41+ min ago (89+ words) A widespread blind spot in one of genomics’ most routine measurements has been brought into sharp focus by a new study comparing short-read and long-read transcriptome sequencing. Researchers report that next-generation sequencing, the short-read workhorse of modern RNA analysis, systematically…...
DNA-Binding Protein Fusions Supercharge PAM-Flexible, High-Precision Base
10+ hour, 58+ min ago (77+ words) Scientists have unveiled a significantly upgraded CRISPR base editing platform that combines near-unrestricted DNA targeting with pinpoint accuracy and markedly higher efficiency, potentially transforming efforts to correct disease-causing mutations and engineer improved crops. In a study published in Advanced Science,…...
Prime Editing Gets a Size Upgrade: Researchers Insert Large DNA Fragments
13+ hour, 50+ min ago (653+ words) The gene-editing field has long faced a stubborn trade-off. Tools such as CRISPR-Cas9 excel at cutting DNA and at making small, targeted changes, but installing large pieces of genetic material into a genome at a precise location — without causing collateral…...
Cryo-EM Reveals How Cas12a Uses a DNA Guide to Hunt RNA Targets
14+ hour, 54+ min ago (741+ words) The CRISPR world has long been organized around a simple division of labor: some Cas enzymes are steered by RNA guides to cut DNA, while others are loaded with DNA guides to find RNA....
Simpler CRISPR-Cas9 System Speeds Genome Editing in Bacillus Bacteria
17+ hour, 12+ min ago (55+ words) Researchers in Germany have unveiled a streamlined genome-editing tool that could make it considerably easier to engineer Bacillus bacteria, a group of microbes that sits at the heart of numerous industrial processes, from enzyme production to the manufacture of vitamins…...
Placenta Gene PHLDA2 Hits Female Fetuses Harder, Mouse Study Finds
17+ hour, 33+ min ago (607+ words) Deep inside the mammalian placenta, a quiet genetic tug-of-war shapes how much a growing fetus asks of its mother....
CRISPR and Surrogate Broodstock Push Aquaculture Toward Programmable
18+ hour, 29+ min ago (747+ words) Aquaculture now supplies more than half of the seafood consumed worldwide, yet the industry still struggles with one of biology’s oldest problems: controlling when and how farmed animals reproduce....
Frost & Sullivan presents the “Global Gene Therapy Crdmo Technology Innovation Leadership Award” to PackGene Biotech Inc.
1+ day, 6+ hour ago (0+ words) ...
CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation
1+ day, 1+ hour ago (67+ words) Cancer has long been understood as a disease of the genome, driven by mutations that rewire the instructions encoded in DNA. Over the past three decades, however, a parallel truth has crystallized: cancer is equally a disease of the epigenome,…...